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Transcriptional profiling of iPSC derived motor neurons from spinal and bulbar muscular atrophy patients at key stages motor neurogenesis

ABSTRACT: Characterise the molecular pathogenesis of androgen receptor spinal and bulbar muscular atrop (SBMA) causing repeat expansion mutations in human motor neurons generated from patient-specific spinal cord motor neurons from induced pluripotent stem cells and performed time-resolved analysis of transcriptomes at key stages of motor neurogenesis. 4 Healthy Controls and 4 SBMA Patient samples analysed at 5 different developemntal stages: iPSCs (d0), post neural induction (d7), post patterning to the pMN domain (d14), post-mitotic but immature iPSC-MNs (d21) and 10 days post-mitotic iPSC-MNs (d28

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Bilal Malik

PROVIDER: E-MTAB-15765 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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