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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional profiling of laser-captured spinal motor neurons in the AR100 mouse model of spinal and bulbar muscular atrophy across disease stages

ABSTRACT: Laser-captured motor neurons (LCM-MN) from spinal cord sections of AR100 SBMA mice and AR20 wild-type controls were isolated at presymptomatic (3 months), symptomatic (12 months), and late-stage (18 months) time points. RNA-seq profiling was performed using Illumina HiSeq paired-end sequencing to investigate transcriptional dynamics underlying motor neuron degeneration in SBMA. Data are provided as raw FASTQ and processed differential expression files.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Bilal Malik

PROVIDER: E-MTAB-15768 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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