IGR_MYOGENIC_STUDY_PD
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Philippe DESSEN
PROVIDER: E-MTAB-1577 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.
Dmitriev Petr P Stankevicins Luiza L Ansseau Eugenie E Petrov Andrei A Barat Ana A Dessen Philippe P Robert Thomas T Turki Ahmed A Lazar Vladimir V Labourer Emmanuel E Belayew Alexandra A Carnac Gilles G Laoudj-Chenivesse Dalila D Lipinski Marc M Vassetzky Yegor S YS
The Journal of biological chemistry 20131020 49
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant hereditary neuromuscular disorder linked to the deletion of an integral number of 3.3-kb-long macrosatellite repeats (D4Z4) within the subtelomeric region of chromosome 4q. Most genes identified in this region are overexpressed in FSHD myoblasts, including the double homeobox genes DUX4 and DUX4c. We have carried out a simultaneous miRNome/transcriptome analysis of FSHD and control primary myoblasts. Of 365 microRNAs (miRNAs) ...[more]
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