The RANK/RANKL axis controls vascular dynamics in the bone marrow

ABSTRACT: Receptor activator of nuclear factor kappa B ligand (RANKL) is an essential cytokine that induces osteoclastic differentiation by monocyte-macrophage lineage precursors. Here, we showed that in addition to its conventional action, RANKL controls vascular permeability in the bone marrow, where it facilitates the mobilization of hematopoietic monocytic cells, including osteoclast precursors, and resultantly regulate bone metabolism. RANK, a cognate receptor for RANKL, is abundantly expressed in sinusoidal endothelial cells and controls vascular permeability by regulating the expression patterns of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1. High RANKL expression was detected in perivascular CXCL12-abundant reticular (CAR) stromal cells. Specific deletion of RANKL

INSTRUMENT(S): 10x Genomics, Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Daisuke Okuzaki 

PROVIDER: E-MTAB-15929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress