Gene expression and immune cell heterogeneity in inbred Amur tiger

ABSTRACT: Inbreeding leads to a reduction in genetic diversity and an elevated likelihood of expressing recessive defective genes, which adversely affect the development of the immune system and render individuals and populations more susceptible to carcinogenic factors, consequently heightening the risk of cancer. Through investigating the function and extent of immune cell interaction in peripheral blood mononuclear cells (PBMCs) of inbred individuals, one can gain a comprehensive understanding of the impact of inbreeding on various aspects of the immune system, including diversity, self-tolerance, immune responsiveness, susceptibility to diseases, and other related areas. Currently, the wild Amur tiger population in China exhibits a moderate degree of inbreeding, with a probability exceeding 90%

INSTRUMENT(S): Illumina NovaSeq X

ORGANISM(S): Panthera tigris altaica

SUBMITTER: Xiaoyun Hu 

PROVIDER: E-MTAB-15936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress