JNK activity provides an intrinsic adaptive phenotype to naive pluripotent cells

ABSTRACT: Cellular adaptation requires a delicate balance between preserving distinct cell identity while maintaining the ability to sense and respond to environmental changes. This is particularly critical during developmental transitions, where cells must adapt to ensure survival without losing their function and fate. The transition between naive and primed pluripotency serves as a unique model for investigating cellular plasticity and adaptability. The transcriptional signatures of naive and primed states are well-characterized, yet the mechanisms that balance state-specific identity with cellular adaptability remain poorly understood. Here, we examined the transcriptional response to osmostress in naive and primed stem cells at a single-cell resolution. Upon stress, primed cells exhibited a ca

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Camille Stephan-Otto Attolini 

PROVIDER: E-MTAB-15979 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress