RNAseq of human aortic endothelial cells (TeloHAECs) under unidirectional flow (UF) and disturbed flow (DF).
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Homo sapiens
SUBMITTER: Shailaja Seetharaman
PROVIDER: E-MTAB-16095 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Mechanosensitive FHL2 tunes endothelial function.
Seetharaman Shailaja S Devany John J Kim Ha Ram HR van Bodegraven Emma E Chmiel Theresa T Tzu-Pin Shentu S Chou Wen-Hung WH Fang Yun Y Gardel Margaret Lise ML
bioRxiv : the preprint server for biology 20240617
Endothelial tissues are essential mechanosensors in the vasculature and facilitate adaptation to various blood flow-induced mechanical cues. Defects in endothelial mechanoresponses can perturb tissue remodelling and functions leading to cardiovascular disease progression. In this context, the precise mechanisms of endothelial mechanoresponses contributing to normal and diseased tissue functioning remain elusive. Here, we sought to uncover how flow-mediated transcriptional regulation drives endot ...[more]
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