SYCP2 recruits HORMAD2 for chromosome-axis-associated ATR signaling, unsynapsed chromatin silencing, and synapsis surveillance in meiosis

ABSTRACT: Meiotic progression in mammals is governed by tightly coordinated transcriptional programs and surveillance mechanisms that ensure the successful pairing, synapsis, and segregation of homologous chromosomes. In spermatocytes, homolog pairing is safeguarded by the pachytene checkpoint, whose mechanism is critically involves meiotic sex chromosome inactivation (MSCI), a silencing mechanism that targets the largely unsynapsed X and Y chromosomes during pachytene. HORMAD2, a HORMA domain-containing protein, plays a key role in MSCI. Although in vitro studies have implicated SYCP2 in recruiting HORMAD proteins to chromosome axes, the mechanism and physiological relevance of this interaction during meiosis has remained unclear. To gain transcriptome-level insights into how loss of HORMAD2 axial

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Arkasarathi Gope 

PROVIDER: E-MTAB-16317 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress