Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNAseq of lung tissue from mice exposed to conventional and renewable diesel exhaust particle


ABSTRACT: Renewable diesel fuels, derived from various biomass sources, have the potential to reduce greenhouse gas emissions and particulate matter (PM) compared to conventional fossil-based diesel. However, the toxicity of emissions from renewable diesel fuels is not yet fully understood. We assessed pulmonary effects of renewable diesel exhaust particles in female C57BL/6Tac mice after a single pulmonary exposure via instatracheal instillation (6, 18, or 54 µg/mouse). Particles were generated from renewable fuels (rapeseed methyl ester, RME; hydrogen-treated vegetable oil, HVO) and petroleum diesel (DEP) using a modern heavy-duty diesel engine. Lung tissue was analysed via RNA sequencing one day post-exposure. Carbon black (Printex 90, 54 µg/mouse) was used as a particle control.

INSTRUMENT(S): Illumina NovaSeq X

ORGANISM(S): Mus musculus

SUBMITTER: Anda Gliga 

PROVIDER: E-MTAB-16322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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