CN analysis of extramedullary plasmacytoma and extramedullary disease of myeloma

ABSTRACT: Extramedullary (or extraosseous) plasmacytoma (EMP) is a localized plasma cell neoplasm lacking apparent bone marrow involvement and other features of multiple myeloma (MM). The prognosis is usually favorable and progression to MM is infrequent. The genetic landscape of EMP remains largely unknown. Importantly, EMP must be distinguished from extramedullary disease of MM (EMD), which typically exhibits aggressive behavior. We performed a comprehensive molecular analysis of EMP (n=24) in comparison to EMD (n=24) using fluorescence in situ hybridization (FISH), copy number (CN) profiling, and targeted next-generation sequencing.

ORGANISM(S): Homo sapiens

SUBMITTER: Julia Salmeron 

PROVIDER: E-MTAB-16327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress