Model based Rational Design of an Oncolytic Virus with Improved Therapeutic Potential

ABSTRACT: Oncolytic viruses are complex biological agents that interact at multiple levels with both tumor and normal tissues. Anti-viral pathways induced by interferon are known to play a critical role in determining tumor cell sensitivity and normal cell resistance to infection with oncolytic viruses. Here we pursue a synthetic biology approach to identify methods that enhance anti-tumor activity of oncolytic viruses through suppression of IFN signaling. Based on the mathematical analysis of multiple strategies, we hypothesize that a positive feedback loop, established by virus-mediated expression of a soluble interferon-binding decoy receptor, increases tumor cytotoxicity without compromising normal cells. Oncolytic rhabodviruses engineered to express a secreted interferon antagonist have improve

ORGANISM(S): Homo sapiens

SUBMITTER: Cory Batenchuk 

PROVIDER: E-MTAB-1636 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress