Biomolecular Condensate Coronas from Nanoparticle Intracellular Processing Are Transferred Between Cells Allowing Cytosolic and Nuclear Access

ABSTRACT: We describe ‘nanomaterial-biological hybrid complexes’ composed partly of an engineered nanoparticle core and formed partly by active processes within cells. Thus magnetic nanoparticles are internalized by cells, undergo active biomolecular deposition to form a new overlaid cell-derived corona layer before being re-exported. We have characterised the exported nanostructures by RNA-seq and proteomics analysis.

INSTRUMENT(S): MGISEQ-2000RS, Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Yan Yan 

PROVIDER: E-MTAB-16398 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress