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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Sc-RNA seq of lung leukocytes isolated from ILC2 deficient , IL4 and IL13 conditional knockout and WT control mice at day 9 post N.brasiliensis infection

ABSTRACT: Many hookworm species migrate through the lung as part of their life cycle and thereby induce tissue damage which primes the development of type 2 immune responses . These responses are crucial for driving the resolution of pathology and for development of adaptive immunity to subsequent infections, something that occurs frequently in natural environments. It is known that ILC2s and Th2 cells, among others, are important for stimulating type 2 immunity but the relative contribution of these cells and whether they are redundant in priming immunity has not been established. Using different mouse strains with conditional Cre recombinase activity we study the relative contribution of ILC2 and Th2 - derived cytokines and ILC2 deficiency in a murine model of helminth infection.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: David Voehringer

PROVIDER: E-MTAB-16580 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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