Targeted non-coding and coding sequencing of SMZL patients
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NovaSeq X
ORGANISM(S): Homo sapiens
SUBMITTER: Helen Parker
PROVIDER: E-MTAB-16840 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:targeted non-coding and coding sequencing of SMZL patients
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Project description:Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin’s lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports have located this loss in the 7q32 region. In order to better characterize the genomic imbalances in SMZL, molecular studies were carried out in 73 patients with SMZL. To gain insight into the mapping at 7q a tiling array was also used. Our results confirmed the presence of a new region of loss on chromosome 7 in these NHL.
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