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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comorbidity-Specific Molecular Programs of Early Diastolic Dysfunction Identify Glucocorticoid Receptor Activation as a Causal Driver in Obesity

ABSTRACT: Early diastolic dysfunction precedes the development of HFpEF, but the molecular events that initiate this process remain poorly defined. HFpEF arises in the setting of systemic comorbidities such as obesity, hypertension, hyperglycemia, and sleep apnea, which often coexist and make it difficult to distinguish their individual contributions to early cardiac remodelling. Here, we aimed to define the early, comorbidity-specific mechanisms that initiate diastolic dysfunction across major HFpEF-associated conditions.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Carlos Torroja

PROVIDER: E-MTAB-16848 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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