Control of Cdc28 CDK1 by a stress-induced lncRNA

ABSTRACT: Genomic analysis has revealed the existence of a large number of long non-coding RNAs (lncRNAs) in a variety of organisms, including yeast. lncRNAs might have several biological functions during normal cell growth and development. Cells are subject to dramatic changes of gene expression in response to environmental changes. Using whole-genome tiling arrays, we found that a set of lncRNAs are induced specifically by the Hog1 stress-activated protein kinase (SAPK) in response to stress. Cdc28 kinase controls the cell cycle in yeast and there is a stress-induced lncRNA in the antisense orientation in CDC28, which permits Hog1 and RSC to induce CDC28 gene expression by remodeling the +1 nucleosome. Increased levels of Cdc28 mediate a more efficient cell cycle re-entry after stress. Therefore,

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Chenchen Zhu 

PROVIDER: E-MTAB-1686 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress