Transcription profiling by array of E. coli NCTC 9001 challenged with four different cationic antimicrobial peptides

ABSTRACT: Obtaining an in depth understanding of the arms races between peptides comprising the innate immune response and bacterial pathogens is of fundamental interest and will inform the development of new antibacterial therapeutics. Many cationic antimicrobial peptides (AMPs) share a range of structural and physical features that have been linked to antibacterial activity and yet they vary dramatically in their potency towards the same bacterial target. We hypothesised that a whole organism view of AMP challenge on Escherichia coli could provide a sophisticated, bacterial perspective enabling understanding of how potency is linked to mode of action. We used a 1H NMR metabolomic approach to characterise the effect on E. coli of challenge with four structurally and physically related AMPs: magaini

ORGANISM(S): Escherichia coli

SUBMITTER: Justyna Kozlowska 

PROVIDER: E-MTAB-1703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress