Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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H3K27Ac and CENPA ChIP-seq experiments for human TeloHAEC cells

ABSTRACT: This data contributes to a telomere-to-telomere genome assembly and annotation of the naked mole-rat, Heterocephalus glaber. To epigenetically annotate centromeres, we performed CENPA ChIP-seq experiments in the male subordinate NMR livers. To ensure antibody quality, as this was the first time CENPA ChIP-seq was performed in the NMR, we performed H3K27Ac and CENPA ChIP-seq experiments on a TeloHAOEC cell line.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Dustin Sokolowski 

PROVIDER: E-MTAB-17311 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology.

Sokolowski Dustin J DJ   Miclăuș Mihai M   Nater Alexander A   Faykoo-Martinez Mariela M   Hoekzema Kendra K   Zuzarte Philip P   Monis Simon S   Alvi Sana Akhtar SA   Erdmann Jason J   Erdmann Archana Lal AL   Kumaragurubaran Rathnakumar R   Bayerl Jonathan J   Yoo DongAhn D   Karimpour Nadia N   Ungerleider Kyra K   Hou Huayun H   J Martin Fergal F   Hourlier Thibaut T   Clarke Zoe Z   Lischer Heidi E L HEL   Leordean Dragos V DV   Jiang Yiyue Y   Pugh Trevor J TJ   Smith Ewan St J ESJ   Haggerty Leanne L   Laird Diana J DJ   Lilue Jingtao J   Holmes Melissa M MM   Eichler Evan E EE   Bruggmann Rémy R   Simpson Jared T JT   Balmus Gabriel G   Wilson Michael D MD  

bioRxiv : the preprint server for biology 20241128

The naked mole-rat (NMR; <i>Heterocephalus glaber</i>) is a eusocial subterranean rodent with a highly unusual set of physiological traits that has attracted great interest amongst the scientific community. However, the genetic basis of most of these traits has not been elucidated. To facilitate our understanding of the molecular mechanisms underlying NMR physiology and behaviour, we generated a long-read chromosomal-level genome assembly of the NMR. This genome was subsequently annotated and in  ...[more]

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