TECTAL GLIOMA VERSUS PILOCYTIC ASTROCYTOMA: REVISITING TUMOR CLASSIFICATION IN LIGHT OF MOLECULAR HETEROGENEITY

ABSTRACT: Two studies originating from the same team have previously suggested the existence of tectal glioma (TG) as a distinct pediatric low grade circumscribed astrocytic tumor type enriched in KRAS alterations or KRAS and BRAF concomitant alterations, and characterized by a distinct methylation profile. Although the majority of these tumors display a pilocytic astrocytoma (PA) morphology, the imprecise terminology of “glioma” was preferred by these authors. The inclusion of the entity “tectal glioma with KRAS mutation” in a future WHO classification is still under discussion. In this context, we performed a comprehensive analysis of 35 glial tumors located in the tectum including clinical, radiological, histopathological, and molecular data. The majority of tumors encountered were pilocytic astr

ORGANISM(S): Yersinia enterocolitica

SUBMITTER: Arnault TAUZIEDE 

PROVIDER: E-MTAB-17457 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress