RNA-seq of rat myocardial tissue to investigate the cardioprotective mechanism of baicalin in myocardial ischemia-reperfusion injury

ABSTRACT: This study aimed to investigate the cardioprotective mechanism of baicalin (BAI) against myocardial ischemia-reperfusion injury (MIRI) in rats. We performed RNA-seq on left ventricular myocardial tissue from three groups: Sham (vehicle control), I/R (ischemia-reperfusion injury model), and I/R+BAI (baicalin treatment 100 mg/kg administered 10 min prior to reperfusion). The goal was to identify differentially expressed genes and key biological pathways affected by baicalin treatment. Transcriptomic analysis revealed that baicalin reversed I/R-induced activation of innate immune pathways, including complement activation, neutrophil degranulation, and TLR signaling.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Rattus norvegicus

SUBMITTER: Peisen Ruan 

PROVIDER: E-MTAB-17471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress