Mouse miR-210 activity in B-cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Richard Coulson
PROVIDER: E-MTAB-1758 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
Mok Yingting Y Schwierzeck Vera V Thomas David C DC Vigorito Elena E Rayner Tim F TF Jarvis Lorna B LB Prosser Haydn M HM Bradley Allan A Withers David R DR Mårtensson Inga-Lill IL Corcoran Lynn M LM Blenkiron Cherie C Miska Eric A EA Lyons Paul A PA Smith Kenneth G C KGC
Journal of immunology (Baltimore, Md. : 1950) 20130819 6
MicroRNAs (MiRs) are small, noncoding RNAs that regulate gene expression posttranscriptionally. In this study, we show that MiR-210 is induced by Oct-2, a key transcriptional mediator of B cell activation. Germline deletion of MiR-210 results in the development of autoantibodies from 5 mo of age. Overexpression of MiR-210 in vivo resulted in cell autonomous expansion of the B1 lineage and impaired fitness of B2 cells. Mice overexpressing MiR-210 exhibited impaired class-switched Ab responses, a ...[more]
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