Data set for "Gene Expression Profiles in Benign Prostate Tissue Reflect Tumor Proximity, Grade, and Molecular subtype

ABSTRACT: Background: Normal tissue in a tumor-bearing organ shows morphological and molecular differences from normal tissue in a tumor-free organ. One explanation to this is that tumors actively instruct adjacent normal tissues to support growth and invasion. The aim of this study was to examine if changes in gene-expression patterns in tumor-adjacent histologically benign prostate tissue, termed tumor instructed normal tissue (TINT), were associated with tumor proximity, grade and molecular subtype and, furthermore, whether they could indicate the presence of high-grade cancer elsewhere in the prostate. Methods: Gene-expression analysis using Clariom D microarrays was performed on matched formalin-fixed paraffin-embedded samples including tumor tissue (n=44), benign prostate tissue taken near (T

INSTRUMENT(S): Microtome, GeneChip Scanner 3000 7G, Thermal cycle, microcenrifuge, vortex mixer, pipettes, Biopsy punch (Ø 6 mm) and microtome, Ionic purification system (Bionano Genomics), Dell laptop, Clariom D Human Transcriptome Arrays (Applied Biosystems, ThermoFisher)

ORGANISM(S): Homo sapiens

SUBMITTER: Eva Freyhult 

PROVIDER: E-MTAB-17721 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress