Gene profiling of Hand2 target genes and transcriptional regulation of Hand2 expression in the postnatal myocardium

ABSTRACT: In humans, cardiac hypertrophy is the principal risk factor for the development of overt heart failure and sudden cardiac death from lethal arrhythmias. Although aberrant reactivation of fetal² gene programs is intricately linked to maladaptive hypertrophy of postnatal cardiomyocytes, loss of cardiac function and heart failure, the transcription factors driving these gene programs remain ill defined. We report that the basic helix-loop-helix (bHLH) transcription factor dHAND/Hand2 is re-expressed in the mammalian postnatal myocardium in response to stress signaling. Interestingly, mutant mice overexpressing Hand2 in otherwise healthy ventricular myocytes developed a phenotype of pathological hypertrophy. In contrast, conditional gene-targeted Hand2 mice demonstrated a marked resistance to

ORGANISM(S): Mus musculus

SUBMITTER: Leon de Windt 

PROVIDER: E-MTAB-1821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress