Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments


ABSTRACT: Flounder fish were exposed in mesocosms for seven months to a contaminated estuarine sediment made by mixing material from the Forth (high organics) and Tyne (high metals and tributyltin) estuaries (FT) or control sediment from the Ythan estuary (Y). Their gene expression profiles were compatred by cDNA microarrays.

ORGANISM(S): Platichthys flesus

SUBMITTER: Tim Williams 

PROVIDER: E-MTAB-1847 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure 'biomarker' signals and induction of inflammatory, innate immune and apoptotic pathways.

Leaver Michael J MJ   Diab Amer A   Boukouvala Evridiki E   Williams Tim D TD   Chipman J Kevin JK   Moffat Colin F CF   Robinson Craig D CD   George Stephen G SG  

Aquatic toxicology (Amsterdam, Netherlands) 20091110 3


The effects of chronic long-term exposure to multiply polluted environments on fish are not well understood, but environmental surveys suggest that such exposure may cause a variety of pathologies, including cancers. Transcriptomic profiling has recently been used to assess gene expression in European flounder (Platichthys flesus) living in several polluted and clean estuaries. However, the gene expression changes detected were not unequivocally elicited by pollution, most likely due to the conf  ...[more]

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