Transcription profiling of mouse Cftr knockout or wild type colonic epithelial cells treated with rosiglitazone

ABSTRACT: 30-day-old Cftr-/- homozygous for the S489X, B6.129P2-Cftr(tm1Unc), mutation or sibling wild-type control mice were treated with standard chow or 20 mg/kg/d rosiglitazone for 5 days. Colonic epithelial cells were extracted and mRNA isolated. Cftr-/- mice suffer from a severe intestinal phenotype including ileo-colonic obstruction resulting from the accumulation of mucin and inspissated material in the lumen.

ORGANISM(S): Mus musculus

SUBMITTER: Narimene Lekmine 

PROVIDER: E-MTAB-188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress