Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Expression profile of TAP tagged Tho2 strain


ABSTRACT: Tho2 protein was tagged with a TAP tag and the gene expression profile was compared to an untagged wildtype strain of the same background using DNA microarrays

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Patrick Kemmeren 

PROVIDER: E-MTAB-1892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II.

Meinel Dominik M DM   Burkert-Kautzsch Cornelia C   Kieser Anja A   O'Duibhir Eoghan E   Siebert Matthias M   Mayer Andreas A   Cramer Patrick P   Söding Johannes J   Holstege Frank C P FC   Sträßer Katja K  

PLoS genetics 20131114 11


Messenger RNA (mRNA) synthesis and export are tightly linked, but the molecular mechanisms of this coupling are largely unknown. In Saccharomyces cerevisiae, the conserved TREX complex couples transcription to mRNA export and mediates mRNP formation. Here, we show that TREX is recruited to the transcription machinery by direct interaction of its subcomplex THO with the serine 2-serine 5 (S2/S5) diphosphorylated CTD of RNA polymerase II. S2 and/or tyrosine 1 (Y1) phosphorylation of the CTD is req  ...[more]

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