Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cyp3a/Mpr2/Mdr1a/1b ko mice

ABSTRACT: Impact of CYP3A and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir

ORGANISM(S): Mus musculus

SUBMITTER: Iris de Rink

PROVIDER: E-MTAB-193 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

ApoE study total (20 and 40 wks)

Project description:Local heart irradiation of 2, 8 or 16 Gy to ApoE-/- mice and follow up tp 20 and 40 weeks. Th goal of this study is to understand microvascular alterations of radiation-induced cardiactoxicity.

2013-01-05 | E-MTAB-930 | biostudies-arrayexpress

Transcription profiling by array of mouse wild type or CD27-/- OT-I T cells are stimulated with artficial antigen presenting cell lines expressing CD70 and/or CD80

Project description:WT or CD27-/- OT-I T cells are stimulated in vitro with artficial antigen presenting cell (aAPC) lines expressing CD70 and/or CD80 for 2, 4, 8 or 14 hours.

2010-09-29 | E-NCMF-38 | biostudies-arrayexpress

Transcription profiling of mouse mesenteric, branchial and axilary lymph nodes from C57Bl/6 femails or CD27 knock out females

Project description:Mesenteric, brachial and axilary lymph nodes from 4 C57Bl/6 females or 5 CD27KO females, both groups were 6 weeks old, were extracted. The different lymph nodes were pooled and a single cell suspension was created. The cell suspension from WT or CD27KO mice was stained with anti-TCRd-PE (GL3) and anti-CD3e-PE Cy7 (2C-11), and FACSorted for double-positive cells on a BD Aria, obtaining around 1 million cells of each sample. These cells were spun down and the pellet was frozen in liquid nitrogen and kept at -80 ÂºC before RNA extraction.

2008-12-01 | E-NCMF-23 | biostudies-arrayexpress

Transcription profiling of mouseWT vs CD137L-/- GC B cells

Project description:WT and CD137L-/- mice of 8-12 weeks old were immunized intra-peritoneally with 50 Âµg chicken gamma- globulin conjugated to 4-hydroxy-3-nitrophenylacetyl (NP-CG) in alum or infected intranasally with 25 hemagglutinin units of influenza virus strain A/NT/60/68 in 50 Âµl HBSS. Nine days after immunization or infection, B cells were enriched from pooled spleens and lymph nodes of 4 mice per test group by means of magnetic labelled bead cell separation (MACS) using anti-mouse BD ImagTM CD45R/B220-particles DM. The B220+ MACS-sorted populations were stained with anti-GL7-FITC and anti-CD19-PE to sort CD19+GL7+ GC and CD19+GL7- non-GC B lymphocytes by flow cytometry on a FACSAria (BD). Around 1 million cells of each sample were obtained. These cells were spun down and the pellet was frozen in liquid nitrogen and kept at -80 ÂºC before RNA extraction.

2009-07-24 | E-NCMF-29 | biostudies-arrayexpress

CD27 signaling in CD8+ T cells in vivo

Project description:Wild type or Cd27-/- mice of 8-12 weeks old were immunized intranasally with 500 ug ovalbumin (OVA) protein and 1 ug cholera toxin in 50 ul HBSS. Spleen, draining lymph node (DLN) or lung were isolated at day 3, day 4 or day 8 after immunization. Single cell suspensions of indicated organs were prepared and OT-I T cells were isolated from this using flow cytometric cell sorting.

2013-08-18 | E-MTAB-1772 | biostudies-arrayexpress

Transcription profiling of human invasive breast cancer carcinomas with different histological types and invasive lobular carcinoma

Project description:Gene expression array analysis on a series of ten different histological special types of invasive breast carcinomas (tubular, micropapillary, mucinous A, mucinous B, endocrine, apocrine, metaplastic, medullary, adenoid cystic, invasive ductal carcinoma with osteoclastic giant cells) and invasive lobular carcinoma.<br><br>Note: this experiment was reloaded into ArrayExpress in August 2010 to include mappings between raw and processed data files. It now includes additional dye-swap combined normalized data files.

2010-08-20 | E-NCMF-3 | biostudies-arrayexpress

Transcription profiling by array of mouse tumours derived from sorted Brca1/p53-deficient cell subpopulations

Project description:Gene expression of tumors derived from sorted Brca1/p53-deficient cell subpopulations

2010-12-15 | E-NCMF-33 | biostudies-arrayexpress

Transcription profiling of pre-injected brain cells from female INK4a/ARF knock-out, BMI1 INK4a/ARF knock-out mice and tumor cells derived from these mice

Project description:Comparison of gene expression profiles between pre-injected brain cells from female INK4a/ARF knock-out, BMI1 INK4a/ARF knock-out mice and tumor cells derived thereof.

2007-11-15 | E-NCMF-4 | biostudies-arrayexpress

Transcription profiling by array of mouse small cell lung cancer tumor samples

Project description:Expressionarray data for A functional role for tumor cell heterogeneity in a mouse model of Small Cell Lung Cancer

2011-02-19 | E-NCMF-37 | biostudies-arrayexpress

Transcription profiling and detection of in vivo protein-DNA interactions in a Burkitts lymphoma cell line using DamID methodology

Project description:-

2009-02-06 | E-NCMF-15 | biostudies-arrayexpress