Salmonella Typhimurium systemic infection of Ity14 mice (spleen tissue)

ABSTRACT: Salmonella-related infections outcome are dependent on the complex interaction between environmental factors, bacterial serotype and host genetic factors. Using ENU chemical mutagenesis, we identified a pedigree named Immunity to Typhimurium 14 (Ity14) carrying a mutation in Stat4 (c.1335+5G>A). Here we used a recognized experimental model of systemic Salmonella Typhimurium infection in mice to study the impact of Stat4 mutation on typhoid-like disease. We compare whole-genome transcriptional profiles between wild-type and Ity14 mutant mice to identify common or unique gene expression profiles between these groups.

ORGANISM(S): Mus musculus

SUBMITTER: Megan Eva 

PROVIDER: E-MTAB-1931 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress