Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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STOX1 placenta w/o aspirin

ABSTRACT: STOX1 overexpressing placentas generate preeclampsia-like symptoms in pregnant mice. These symptoms are reverted by aspirin. The experiment aims at analyzing placental expression in Transgenic/non transgenic with and withou aspirin, in the placentas at 16,5 days post-coïtum. There are two strains of transgenic mice that express the transgene at different levels: STOX42 about 15 fold that of STOX13. STOX13 expressed the human STOX1 roughly at the level of the mouse endogeneous Stox1 in the placenta.

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Vaiman 

PROVIDER: E-MTAB-1970 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene.

Doridot Ludivine L   Châtre Laurent L   Ducat Aurélien A   Vilotte Jean-Luc JL   Lombès Anne A   Méhats Céline C   Barbaux Sandrine S   Calicchio Rosamaria R   Ricchetti Miria M   Vaiman Daniel D  

Antioxidants & redox signaling 20140620 6

<h4>Aims</h4>Storkhead box 1 (STOX1) is a winged-helix transcription factor that is implicated in the genetic forms of a high-prevalence human gestational disease, pre-eclampsia. STOX1 overexpression confers pre-eclampsia-like transcriptomic features to trophoblastic cell lines and pre-eclampsia symptoms to pregnant mice. The aim of this work was to evaluate the impact of STOX1 on free radical equilibrium and mitochondrial function, both in vitro and in vivo.<h4>Results</h4>Transcriptome analysi  ...[more]

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