Aspergillus fumigatus RNA-Seq reads control v.s. DTT or TM induced

ABSTRACT: The unfolded protein response (UPR) is a network of intracellular signaling pathways that supports the ability of the secretory pathway to maintain equilibrium between the load of proteins entering the endoplasmic reticulum (ER) and the protein folding capacity of the ER lumen. Current evidence suggests that human pathogenic fungi rely heavily on this pathway for virulence, but there is limited understanding of the mechanisms involved. The best known functional output of the UPR is transcriptional upregulation of mRNAs involved in ER homeostasis. However, this does not take into account mechanisms of translational regulation that involve differential recruitment of mRNAs to ribosomes. In this study, a global analysis of transcript-specific translational regulation was performed in the p

INSTRUMENT(S): Illumina HiSeq 1000

ORGANISM(S): Aspergillus fumigatus

SUBMITTER: Zhaowei Ren 

PROVIDER: E-MTAB-2028 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress