Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Complete dosage compensation and sex-biased gene expression in Manduca sexta


ABSTRACT: Using 4 replicate males and 4 replicate females this experiment examined dosage compensation and sex-biased gene expression. Briefly we performed a de novo assembly of the Manduca sexta transcriptome using all sequenced libraries, quantified genes expression, identified the physical locations of genes through orthology to the moth Bombyx mori and examine expression differences between autosomal and Z-linked genes between males and females. Further, we examined sex-biased gene expression using the replicated data.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Manduca sexta

SUBMITTER: Gilbert Smith 

PROVIDER: E-MTAB-2066 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta.

Smith Gilbert G   Chen Yun-Ru YR   Blissard Gary W GW   Briscoe Adriana D AD  

Genome biology and evolution 20140301 3


Sex chromosome dosage compensation balances homogametic sex chromosome expression with autosomal expression in the heterogametic sex, leading to sex chromosome expression parity between the sexes. If compensation is incomplete, this can lead to expression imbalance and sex-biased gene expression. Recent work has uncovered an intriguing and variable pattern of dosage compensation across species that includes a lack of complete dosage compensation in ZW species compared with XY species. This has l  ...[more]

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