Oncogenic FIP1L1-PDGFR-alpha signaling: influence of subcellular localisation and unconventional STAT activation

ABSTRACT: Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRa kinase exhibits a significantly different signaling pattern compared to PDGFRa wildtype: Interestingly, the conventional strong activation of PI3-kinase- and MAP-kinase- pathways is remarkably shifted towards a prominent activation of STAT factors. This diverging signaling pattern compared to classical PDGF-receptor signaling is partially coupled to the aberrant intracellular location of the oncogene, since membrane targeting of F/PDGFRa restores activation of MAPK- and PI3K-pathway completely. In contrast to the M-^SclassicalM-^T cytokine-induced STAT-activ

ORGANISM(S): Homo sapiens

SUBMITTER: Arnaud Muller 

PROVIDER: E-MTAB-2102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress