T1AM in rat liver tissue

ABSTRACT: Thyroid hormones (THs) influence adipose tissue development and metabolism. They regulate both adipocyte proliferation and differentiation and, as they increase the metabolic rate, may be helpful for obesity treatment. However, due to their cardiotoxic effects, like tachycardia and arrhythmia, their use is limited to hypothyroid obese patients. Interestingly, some TH metabolites have been recently shown to possess the same beneficial metabolic effects as THs without any negative effect. The biogenic amine 3-Iodothyronamine (T1AM), for example, affects carbohydrate and lipid metabolism without undesirable side effects. In mice T1AM exhibits cardiac effects opposite to those associated with thyroid hormones, like bradycardia, and, in isolated working rat hearts, produces a rapid, reversible,

INSTRUMENT(S): the Agilent scanner G2565BA, NanoDrop ND-1000 Spectrophotometer (NanoDrop Technologies), Agilent�s Microarray Hybridization Oven

ORGANISM(S): Rattus norvegicus

SUBMITTER: Veronica Mariotti 

PROVIDER: E-MTAB-2178 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress