Nitrogen regulatory protein C couples nitrogen stress response and stringent response in nitrogen starved Escherichia coli.

ABSTRACT: We show that NtrC couples the Ntr stress response and stringent response in N starved E. coli, which appears to be a conserved adaptive strategy employed by many bacteria to manage conditions of nutritional adversity. N starved Escherichia coli initiate the nitrogen regulation (Ntr) stress response as an adaptive mechanism to scavenge for alternative N sources. The Ntr stress response requires the global transcriptional regulator nitrogen regulatory protein C (NtrC). We discovered that the transcription of relA, the key gene responsible for the synthesis of the major effector nucleotide alamorne of the bacterial stringent response, guanosine pentaphosphate (ppGpp), is positively regulated by NtrC in N starved E. coli. we addressed Ntr stress response-ppGpp alarmone links and mapped the gen

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

SUBMITTER: Barton Geraint 

PROVIDER: E-MTAB-2211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress