Genome-wide expression analysis of human white blood cells in patients with stroke and/or obesity compared with healthy individuals

ABSTRACT: Obesity is well recognized as a risk factor for coronary heart disease and mortality. The relationship between abdominal obesity and ischemic stroke remains less clear. Previous publication showed the obesity is an independent, potent risk factor for ischemic stroke in all race-ethnic groups. It is a stronger risk factor than BMI and has a greater effect among younger persons. The goal of this experiment was to compare the global transcriptional profile, and its regulation, of white blood cells of healthy normals, patients with obesity and/or stroke in order to understand the transcriptional differences behind the different phenotypes. There were 6 subjects in each group. RNA was purified from white blood cells using a TRIZOL RNA Isolation Protocol (Life technologies) and 500 ng of startin

ORGANISM(S): Homo sapiens

SUBMITTER: Javier Campion 

PROVIDER: E-MTAB-2312 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress