Bone signaling in rat middle ear and cochlea by transcription profiling

ABSTRACT: * Bone signaling in middle ear development *
Common middle ear diseases, such as chronic suppurative otitis media and cholesteatoma, may affect bone behavior in the middle ear air cell system.
This study analyzed gene expression of bone-related signaling factors and gene sets from lining tissues in the developing middle ear of the rat. Candidate gene products were compared with previously published data on middle ear bone metabolism.
Microarray technology was used to identify bone-related genes and gene sets, which were differentially expressed between the adult (quiescent) bulla and young (resorbing/forming) bulla.

* Gene expression of the otic capsule *
The behavior of bone cells within the otic capsule is unique. After occification localized bone re

ORGANISM(S): Rattus norvegicus

SUBMITTER: Tomas Martin-Bertelsen 

PROVIDER: E-MTAB-2336 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress