Transcription profiling by array of P19CL6 cells transfected with Art27 siRNA to identify Art27 regulated transcripts
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kumiko Tanaka
PROVIDER: E-MTAB-2337 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
Carter Daniel R DR Buckle Andrew D AD Tanaka Kumiko K Perdomo Jose J Chong Beng H BH
PloS one 20140417 4
Transcription factors play a crucial role in regulation of cardiac biology. FOG-2 is indispensable in this setting, predominantly functioning through a physical interaction with GATA-4. This study aimed to identify novel co-regulators of FOG-2 to further elaborate on its inhibitory activity on GATA-4. The Art27 transcription factor was identified by a yeast-2-hybrid library screen to be a novel FOG-2 protein partner. Characterisation revealed that Art27 is co-expressed with FOG-2 and GATA-4 thro ...[more]
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