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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Bone marrow erythroblast arrays

ABSTRACT: JAK2V617F mutation is found in most patients with a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET). We have demonstrated that heterozygous human JAK2V617F are associated with ET-like phenotypes while homozygosity for human JAK2V617F results in a striking phenotypic switch from an ET-like to PV-like phenotype. The resultant erythrocytosis is driven by increased numbers of erythroid progenitors and enhanced erythroblast proliferation. To establish the molecular mechanisms and pathways involved in the erythrocytosis, microarray was performed on bone marrow erythroblasts isolated from 8-10 weeks old homozygous, heterozygous mice and wildtype controls (3 mice for each genotype).

ORGANISM(S): Mus musculus

SUBMITTER: Juan Li

PROVIDER: E-MTAB-2427 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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