Transcriptional responses in liver upon acute CCl4 intoxication

ABSTRACT: Since xenobiotics enter the organism via the liver, hepatocytes must cope with numerous perturbations. In particular, exposure to hepatotoxic agents resulting in liver injury triggers a strong alteration in gene expression. The contribution of these transcriptional regulatory networks to the propagation of injury (i.e. by modulation of metabolic pathways, inflammation, proliferation) are not fully understood. Therefore, we conducted a time-resolved gene array study on mouse liver after exposure to a single intraperitoneal injection of the hepatotoxic compound carbon tetrachloride (CCl4). This model induces a transient injury which reaches its maximum between 2 to 3 days after injection, followed by a precise regenerative response. The experiment included early time points (i.e. 2 and 8h) a

ORGANISM(S): Mus musculus

SUBMITTER: Patricio Godoy 

PROVIDER: E-MTAB-2445 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress