RNA-seq of achilles tendon from young and old donors to study age-related changes in tendon
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000
ORGANISM(S): Homo sapiens
SUBMITTER: Mandy Peffers
PROVIDER: E-MTAB-2449 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptome analysis of ageing in uninjured human Achilles tendon.
Peffers Mandy Jayne MJ Fang Yongxiang Y Cheung Kathleen K Wei Tim Koh Jia TK Clegg Peter David PD Birch Helen Lucy HL
Arthritis research & therapy 20150218
<h4>Introduction</h4>The risk of tendon injury and disease increases significantly with increasing age. The aim of the study was to characterise transcriptional changes in human Achilles tendon during the ageing process in order to identify molecular signatures that might contribute to age-related degeneration.<h4>Methods</h4>RNA for gene expression analysis using RNA-Seq and quantitative real-time polymerase chain reaction analysis was isolated from young and old macroscopically normal human Ac ...[more]
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