Transcriptome analysis of human astrocytes upon FGF1 stimulation
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Anita Friese
PROVIDER: E-MTAB-2485 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination.
Mohan Hema H Friese Anita A Albrecht Stefanie S Krumbholz Markus M Elliott Christina L CL Arthur Ariel A Menon Ramesh R Farina Cinthia C Junker Andreas A Stadelmann Christine C Barnett Susan C SC Huitinga Inge I Wekerle Hartmut H Hohlfeld Reinhard R Lassmann Hans H Kuhlmann Tanja T Linington Chris C Meinl Edgar E
Acta neuropathologica communications 20141211
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS lesions remyelinates completely. Enhancing remyelination is, therefore, a major aim of future MS therapies. Here we took a novel approach to identify factors that may inhibit or support endogenous remyelination in MS. We dissected remyelinated, demyelinated active, and demyelinated inactive white matter MS lesions, and compared transcript levels of myelination and inflammation-related genes using q ...[more]
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