Ontology highlight
ABSTRACT:
INSTRUMENT(S): Axon GenePix 4000B scanning hardware
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Lakxmi Subramanian
PROVIDER: E-MTAB-2549 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature communications 20140609
DNA double-strand break (DSB) repair is a highly regulated process performed predominantly by non-homologous end joining (NHEJ) or homologous recombination (HR) pathways. How these pathways are coordinated in the context of chromatin is unclear. Here we uncover a role for histone H3K36 modification in regulating DSB repair pathway choice in fission yeast. We find Set2-dependent H3K36 methylation reduces chromatin accessibility, reduces resection and promotes NHEJ, while antagonistic Gcn5-depende ...[more]