Priming hepatocytes into G2 phase reverses age-related regenerative impairments in livers of elderly mice

ABSTRACT: Frozen liver tissue from 24 month old C57BL/6 mice; control or each of the other three treatment groups taken pre and 36 hour post hepatectomy were used for analysis (n=2 per group). Mice were administrated intraperitoneally with one of the following agents every day for 7 days and 10 minutes before hepatectomy or hepatocyte isolation: 0.5 ml of saline, 500 umol alpha-aminobutyric acid or 500 umol gamma-aminobutyric acid in 0.5ml of saline. Mice in control group received no pre-administrations.

INSTRUMENT(S): Fluidics workstation, HP desktop

ORGANISM(S): Mus musculus

SUBMITTER: Fatima Rehman 

PROVIDER: E-MTAB-2810 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress