Physical activity diminish fatigue and systemic interferon response in multiple sclerosis

ABSTRACT: Objective: To evaluate gene expression profiles in multiple sclerosis (MS) patients who improved their fatigue status after a program of physical exercise and to compare them with healthy controls (HC). Methods: A prospective longitudinal study was conducted. Gene expression in whole blood was profiled at baseline in 7 healthy controls and also in 7 fatigued-MS patients. Patients underwent a physical exercise program for 6 months, and their fatigue status and gene expression profiles were again analyzed at the end of this program. Results: MS patients showed a significant activation of genes participating in the systemic interferon response in comparison with healthy controls. Fatigue improved at the end of the physical activity program, and, in parallel, systemic activation of interferon

ORGANISM(S): Homo sapiens

SUBMITTER: Raquel Almansa 

PROVIDER: E-MTAB-2973 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress