Expression analysis in hESCs with HPAT5-KO

ABSTRACT: Long intergenic noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and play essential roles in diverse biological processes. Their expression is often restricted to distinct developmental contexts and often exhibits precise cell- and/or tissue-specific localization. Recent studies demonstrated that their sequences are highly enriched for repetitive elements (REs) of retroviral origin that might have contributed to their evolution and function-acquisition through development. However, the molecular mechanism(s) by which they regulate gene networks in a cell type-specific manner is largely unknown. Here, we used single-cell gene expression profiling during nuclear reprogramming and identified three endogenous retrovirus 1 (ERV1)-derived lincRNAs (HPAT2, 3 a

ORGANISM(S): Homo sapiens

SUBMITTER: Jens Durruthy Durruthy 

PROVIDER: E-MTAB-2994 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress