Gene expression profiling of MafA, MafB, and MafA/MafB Mutants in E18.5 pancreas

ABSTRACT: MafA and MafB transcription factors have been shown to be key regulators of insulin and glucagon transcription. MafB is essential for alpha and beta cell differentiation, as MafB deficient mice produced fewer insulin+ and glucagon+ cells during development, with MafA expressed in remaining insulin+ cells. In contrast, beta cell development was reported to be normal in a total MafA knock out, although the animals developed beta cell dysfunction and diabetes as adults. However, we have found that MafB expression is elevated during development and retained in adult insulin+ cells after conditional removal of MafA in the pancreas. These studies will evaluate the broader significance of these insulin and glucagon regulators in alpha and beta cell development and function. Our efforts will focus

INSTRUMENT(S): Agilent DNA Microarray Scanner Model #G2565BA

ORGANISM(S): Mus musculus

SUBMITTER: Roland Stein 

PROVIDER: E-MTAB-3070 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress