Autophagy is essential for tumor development and survival in hypoxia and in vivo in glioblastoma. (Provisional)

ABSTRACT: Hypoxia is negatively associated with glioblastoma patient survival and contributes strongly to tumor resistance. Unfortunately novel anti-angiogenic therapy increases hypoxia and activates survival pathways in tumor cells leading to inevitable tumor relapse. Here we demonstrate that primary glioma cultures and cell lines depend on autophagy to survive severe hypoxia but also at normal oxygen levels. Positive regulators of autophagy are expressed at higher levels in tumor cells and induction in severe hypoxia is more prominent compared to normal brain cells. We demonstrate that autophagy is an essential/critical target for novel treatment in glioblastoma. We show ATG9A is induced by severe hypoxia and could be a novel player of the autophagic response in glioma cells. ATG9A targeting inhib

ORGANISM(S): Homo sapiens

SUBMITTER: Arnaud Muller 

PROVIDER: E-MTAB-3085 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress