Gene expression analysis of hippocampal tissue from epilepsy surgery

ABSTRACT: Samples used in the study originated from three UK sites: the Walton Centre for Neurology and Neurosurgery in Liverpool, the Salford Royal Hospital in Salford and the Southern General Hospital in Glasgow. We recruited patients with pharmacoresistant mesial temporal lobe epilepsy for whom a therapeutic temporal lobectomy was being undertaken. After surgery, the hippocampus was divided into two portions: (1) one portion was preserved for RNA isolation, and (2) the other portion underwent histological analysis by an experienced neuropathologist. Frozen post-mortem histologically-normal hippocampal samples from donors with no known brain diseases were obtained from the MRC Edinburgh Brain Bank (Edinburgh, UK) and the Queen Square Brain Bank (London, UK). Brain samples were disrupted and ho

ORGANISM(S): Homo sapiens

SUBMITTER: Nasir Mirza 

PROVIDER: E-MTAB-3123 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress