Regression analysis of response of hepatic transcriptome to dietary docosahexaenoic acid in post-smolt Atlantic salmon (Salmo salar)

ABSTRACT: The present study aimed to determine the impact of dietary docosahexaenoic acid (DHA) on the metabolism of Atlantic salmon (Salmo salar). The effects of diets containing increasing levels of DHA (1 g kg-1, 5 g kg-1, 10 g kg-1, 15 g kg-1 and 20 g kg-1) on the liver transcriptome of post-smolt salmon was determined using regression analysis to elucidate patterns of gene expression and responses of specific metabolic pathways. Total RNA was isolated from liver of individual fish and analyzed using a custom 44K Atlantic salmon oligo-microarray. The expression of up to 911 unique annotated genes was significantly affected by dietary DHA inclusion relative to a low DHA reference diet. Using regression analysis, 797 unique genes were found with a significant linear correlation between expression

ORGANISM(S): Salmo salar

SUBMITTER: Mónica Betancor 

PROVIDER: E-MTAB-3180 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress