Identification of a blood-borne miRNA signature of synovial sarcoma

ABSTRACT: Synovial sarcomas account for approximately 10% of all soft-tissue tumors and occur most frequently in young adults. A specific translocation in this sarcoma induces fusion of the SYT gene on chromosome 18 to the SSX genes on chromosome X, leading to proliferation of the tumor cells. The need for non-invasive biomarkers indicating recurrence and activity of this disease has sparked research into short non-coding RNA known as microRNA (miRNA). Patients and Methods: Blood samples of patients with active synovial sarcoma and of healthy donors were collected. Whole blood RNA was extracted and analyzed using an Affymetrix GeneChip miRNA Array v. 4.0. Results: Hierarchical clustering of all covered human mature miRNAs and human pre-miRNAs separated sarcoma samples from control samples. Followi

INSTRUMENT(S): none

ORGANISM(S): Homo sapiens

SUBMITTER: Dietmar Pfeifer 

PROVIDER: E-MTAB-3273 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress